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Volume 2 Issue 1

Review Article: CRISPR/Cas9: a Revolution towards Treatment for Neurodegenerative Disorders

Mariyam Amin, Kinza Shahid, Rubab Nasir, Ifra Alam and Pervez Anwar*

Age-dependent disorders in terms of neurodegenerative disorders are highly reported for progressive neural dysfunction. Animal models are exceptionally meaningful to assimilate the pathogenesis and treatment of neurodegenerative disorders. Small animals evoke pathological limitations as compared to large animals. CRISPR/Cas9 is a novel technique widely used to modify genome of many species using gene therapy approach. CRISPR/Cas9 is capable to correct DNA sequences by non-homologous end joining and homologous directed repair mechanisms. In this review, we illustrate the use of CRISPR/Cas9 to generate embryonic DNA in brain cells. We also describe the use of CRISPR/Cas9 technology by using knock out approach to generate transgenic animal models for rare neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS), Friedreich Ataxia (FRDA), and Neuronal Ceroid Lipofuscinoses (NCLs) to treat their causative agents.

Cite this Article: Amin M, Shahid K, Nasir R, Alam I, Anwar P. CRISPR/Cas9: A Revolution towards Treatment for Neurodegenerative Disorders. Open J Biotechnol Bioeng Res. 2018;2(1): 001-008.

Published: 10 February 2018

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