International Journal of Nephrology & Therapeutics

E-ISSN: 2161-0959
Pubmed NLM Abbr: Int J Nephrol Ther
Journal Full Title: International Journal of Nephrology & Therapeutics
Website: Click here
DOI: 10.37871 (CrossRef)
Review Process type: Double Blind
Publication fee: Click here
Plagiarism checker: iThenticate
Language: English
Ability to collect research papers: Worldwide
Organized by: SciRes Literature

License: Creative Commons License Open Access by International Journal of Nephrology & Therapeutics is licensed under a Creative Commons Attribution 4.0 International License. Based on a work at SciRes Literature..

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Research Articles

Nephroblastoma: Profile and Management Outcome in a Tertiary Hospital in a Developing Country 08/05/2021

Can ENZOTEIN (Proteolytic Enzyme Fortifi ed Protein Supplement) be an Effective Alternative as Low Dose Protein Supplement in Malnourished Low Income End Stage Renal Disease Patients? 10/10/2020

Antibiotic Resistance of Planktonic and Biofi lm Forms of E. coli to Soluble Nitrofurans 07/24/2020

Efficacy of Sevelamer Carbonate versus Lanthanum Carbonate as a Phosphate Binder in CKD Stage 3 To 5 06/29/2019

Frequency of Ischemic Heart Disease in Patients with End Stage Renal Disease 05/09/2019

Review Articles

Renovascular Hypertension 01/27/2021

Diagnosis and Treatment Status and Progress of Autosomal Dominant Polycystic Kidney Disease 11/27/2017

Articles

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Hanna Balakier, CReATe Fertility Centre, Toronto, ON, Canada

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International Journal of Neurological Disorders

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Senior Resident of Internal Medicine, Khartoum, Sudan

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International Journal of Virology & Infectious Diseases

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Christian-Albrechts University, Germany

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University of Florence, Italy

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Wayne Carter

University of Nottingham, United States

Biography:

Wayne Carter research & development career has been concerned with understanding cellular signaling and the protein changes and modifications that can trigger pathology, and how therapeutics can limit disease progression. Many extracellular signals bind to specific trans-membranous receptors to initiate a cellular signaling pathway. Signal transduction invariably requires protein post-translational modifications (PTMs) to propagate intracellular signaling events. Additionally, PTMs arise from extracellular xenobiotic agents that cross cell membranes. An example is environmental pesticides that can adduct cellular proteins including a number of specific neuronal targets. Other toxic agents such as alcohol trigger protein PTMs and damage to tissues and cellular proteins.

By utilizing proteomic strategies she characterised the cellular damage that arises from these agents, and their specific cellular and nuclear (epigenetic) protein targets. One such protein target is protein isoaspartyl methyltransferase (PIMT), an enzyme that normally repairs age-related protein damage, and whose activity is impaired by alcohol consumption.

Research Interest(s): Current laboratory studies include an examination of the targets and consequences of environmental pesticide exposures; hepato- and neuro-pathology of alcohol abuse; and studies of the protein PTMs and protein aggregation in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.