Krishna Chattopadhyay^1*, Somashree Biswas², Subrata Mukhopadhyay¹ and Brajadulal Chattopadhyay²

Topic: Nicotine, the core addictive component presents in a substantial quantity in tobacco. Addiction of nicotine in female populations especially who belong to lower socio-economic status causes many adverse effects, like inducing oxidative stress, genotoxicity and disrupting immune response in the body. The investigation was designed to determine first time the improved efficacy of nanocurcumin against aggravated nicotine-induced toxicity on female system.
Experiments: Experiments were conducted on female albino rats maintained under protein malnourished condition where animals were subcutaneously injected with effective dose of nicotine (2.5 mg kg-1 body weight day-1) and orally supplemented with effective dose of nanocurcumin (4 mg kg-1 body weight day-1) for 21 days. The animals were then sacrificed and various biochemical and histological experiments were performed on serum and different tissues.
Significant Findings: Disruption of liver and kidney functions, alteration of phosphatase enzymes activities, triglycerides and total cholesterol in serum and aggravated lipid peroxidation in serum and liver tissues were observed in nicotine-induced and protein malnourished condition. Nicotine also decreased the antioxidant enzymes activities and disrupted severely the structural integrity of liver, kidney and ovary tissues in such condition. Supplementation of nanocurcumin restored the normalcy of various biochemical functions and maintained the structural integrity of liver, kidney and ovarian tissues.
Conclusions: Nanocurcumin exhibited more effective (P < 0.001) amelioration than curcumin against the deleterious nicotine-induced toxicities and therefore, it can be used as a potential therapeutic blocker for protecting the health of malnourished female population against nicotine.
Keywords: Antioxidant; Nanocurcumin; Nicotine toxicity; Oxidative stress; Malnourished

Cite this Article: Krishna C, Biswas S, Mukhopadhyay S, Chattopadhyay B. Amelioration of Nicotine Induced Toxicity by Nanocurcumin in Protein Malnourished Condition. Sci J Biol. 2018;1(1): 001-008.

Published: 07 July 2018