Idrissi Serhrouchni K^1*, Hammas N², El Fatemi H², Chbani L², Harmouch T² and Amarti A²

Primary malignant schwannoma is a rare neoplasm of nerve sheath origin. It is a cancer of the connective tissue surrounding nerves. Given its origin and behavior it is classified as sarcoma. The estimated incidence of Malignant Peripheral Nerve Sheath Tumor (MPNST) in general population is 0.001% and in patients with Neurofibromatosis 1 (NF-1) is 2-5%. It is an uncommon spindle cell sarcoma accounting for approximately 5% of all soft-tissue sarcoma. They are highly aggressive and occur in the second or third decade. This neoplasm usually affects the extremities. There is strong association between MPNSTs and neurofibromatosis (NF-1) and previous irradiation. We present the case of a 61-year-old woman manifesting with recurrent sciatalgy near for the fourth and fifth lumbar vertebral bodies. She underwent resection of a mass at the L4-5 level that was subsequently recognized as a malignant peripheral nerve sheath tumor.
Keywords: Malignant Peripheral Nerve Sheath Tumor (MPNST); Neurofibromatosis; Protein S100

Cite this Article: drissi Serhrouchni K, Hammas N, El Fatemi H, Chbani L, Harmouch T, et al. Malignant Peripheral Nerve Sheath Tumor Rare Neurological Isolated Neoplasm. Int J Neurol Dis. 2019;3(1): 001-003.

Published: 08 January 2019