Agoro ES^1*, Wankasi MM², and Zebedee UL³

Introduction: Carbon Monoxide (CO) is a colourless, odourless and euphoric gas produced as a result of incomplete combustion of organic materials. It could either cause morbidity or mortality depending on the concentration and duration of exposure.
Aim: The aim of this study was to examine the long term effect of CO inhalation on haematological parameters.
Materials and Methods: Twenty (20) rabbits were utilized for the study as supported by Mead's resource equation. Carbon monoxide used for the study was sourced from portable generating set (SUMEC). The study was divided into four groups; controls, ten days, twenty days and thirty days' exposures respectively. All the groups except the control were exposed daily to mild CO concentration for 30 minutes for the durations of the study. Blood sample were extracted using standard procedures. The haematological parameters analysed included full blood count, red cell indices and film reading. The samples were analyzed using SYSMEX Automated Blood Count machine (SYSMEX KX-21N ANALYZER) and microscopy for blood film reading.
Results: Data were analyzed by one-way Anova (Post Hoc-LSD) with statistical significance considered at p-value < 0.05 using Statistical Package for Social Science (SPSS) 18-20 version. The results showed that RBCs, lymphocytes and basophils were significantly raised (P < 0.05). On the contrary, platelets, white blood cell, neutrophils, monocytes, eosinophils, MCV, MCH and MCHC were significantly decreased (P < 0.05).
Conclusion: In conclusion, the findings of the study revealed that chronic CO inhalation has the predisposition of distorting haematological profiles.
Keywords: Haematological parameters; White Cell differential; Red Cell indices; Carbon monoxide

Cite this Article: Agoro ES, Wankasi MM, Zebedee UL. The Effects of Chronic Carbon Monoxide Intoxication on Some Haematological Parameters and Films in Rabbits. Adv J Toxicol Curr Res. 2019;3(1): 001-005.

Published: 23 January 2019