Monika Kapoor, Neha Sharma* and Bimla Nehru

Gut microflora is a huge reservoir of Lipopolysaccharide (LPS), an endotoxin which is the main component of external cell wall of gram negative bacteria. A balance exists between the gut microflora and host, the disruption of which leads to many diseases and inflammatory cascades. Various studies have shown that change in gut permeability promote the translocation of microbes into the liver via portal circulation and results in activation of immune system. Along with liver, many other organs are also getting affected including brain and kidney. Literature also revealed that the spinach leaf extract is rich in several active components; including flavonoids and hence exhibit anti-oxidative, anti-proliferative and anti-inflammatory properties in biological system. The present study was aimed to explore the protective potentials of the Spinach Leaf Extract (SLE) (50 mg/kg b.w) against the systemic LPS (5mg/kg b.w) induced toxicity by evaluating several toxicological parameters such as increased oxidative burden in organs as depicted from compromised antioxidant defence system (including Glutathione System, MDA levels, Catalase activity), cytokine levels and blood glucose levels. This was further supported by results from histopathological studies. Accordingly, supplementation with SLE to LPS treated mice showed marked improvement in the above altered parameters. Histopathological study also depicted improved histoarchitecture in liver, kidney and brain after SLE supplementation. Above stated data suggested that treatment with spinach leaf extract protects against LPS induced multiple organ failure by virtue of its antioxidant properties. It also protects by acting on multifactorial pathways simultaneously therefore, its therapeutic potentials should be explored further.
Keywords: Lipopolysaccharide; Multiple organ dysfunctions; Oxidative burden; Inflammation; Spinach leaf extract

Cite this Article: Kapoor M, Sharma N, Nehru B. Spinach Leaf Extract Ameliorates Multiple Organ Dysfunction Induced by Lipopolysaccharide Exposure in Animal Model of Parkinson's Disease. Alzheimers Parkinsons Dis Open Access. 2017;3(1): 001-009.

Published: 18 August 2017